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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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Cytokine synthesis in human peripheral
blood mononuclear cells after oral administration of polyenzyme
preparations
1Desser L., 1Rehberger
A., 1Kokron E., 2Paukovits
W.
1Institute of Experimental and Applied Oncology
2Institute for Tumor Biology-cancer Research,
University of Vienna, Austria
Oncology 1993, 50, pp. 403-407
SO 77 (2-04-1) |
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Abstract
Pharmaceutical preparations containing mixtures of various
proteolytic and nonproteolytic enzymes have been suggested
for use in the treatment of malignant diseases. However,
the mode of action of such preparations was not clear. We
have shown before that intact bromelain, papain or amylase,
which are components of a commercial polyenzyme preparation,
induce cytokine production in peripheral blood mononuclear
cells in vitro. IFN-a and IFN-g which had no effect alone,
synergistically increased TNF production when applied together
with the enzymes. Here we show that trypsin alone had only
a small inducing effect. The tryptic but not the autolytic
fragments of papain and bromelain have a higher (10- to 40-fold)
inducing capacity for TNF production than the untreated enzyme.
Additionally we demonstrate that after ingestion of milligram
doses of the polyenzyme preparation (as recommended for clinical
use), PBMNC of healthy donors acquire the ability to produce
TNF-a, IL-1b and IL-6 when incubated ex vivo with IFN-g.
Our results indicate that the biological effects observed
after oral administration of polyenzyme preparations are
realted to their ability to induce cytokine production. This
may explain the antitumor effects of such enzymes. Our results
also suggest that polyenzyme preparations may have a stronger
immunomodulary effect when used in combination with IFN-g.
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