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WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
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A multi-centre, double-blind study of serrapeptase
versus placebo in post-antrotomy buccal swelling.
Author: Tachibana M, Mizukoshi O, Harada Y, Kawamoto K,
Nakai Y.
Source: Pharmatherapeutica. 1984;3(8):526-30.
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| A multi-centre, double-blind, placebo-controlled
trial was carried out to investigate the clinical efficacy
of the anti-inflammatory enzyme serrapeptase in a total of
174 patients who underwent Caldwell-Luc antrotomy for chronic
empyema. Eighty-eight patients received 10 mg serrapeptase
3 times on the day before operation, once on the night of the
operation and 3 times daily for 5 days after operation; the
other 86 received placebo. Changes in buccal swelling after
operation were observed as a parameter of the response to treatment.
The degree of swelling in the serrapeptase-treated patients
was significantly less than that in the placebo-treated patients
at every point of observation after operation up to the 5th
day (p less than 0.01 to p less than 0.05). Maximal swelling
throughout all the post-operative points of observation was
also significantly smaller in size in the serrapeptase-treated
group than in the placebo-treated group. No side-effects were
reported. |
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