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WAM Essentials, Inc.
Systemic Enzyme Therapy
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Augmentation by serrapeptase of tissue
permeation by cefotiam
Koyama A, Mori J, Tokuda H, Waku M, Anno H, Katayama T,
Murakami K, Komatsu H, Hirata M, Arai T, et al.
Jpn J Antibiot. 1986 Mar;39(3):761-71. |
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Cefotiam (CTM) is a new cephalosporin with a
broad spectrum of activity against both Gram-positive and Gram-negative
microorganisms. Cephalosporins are widely used for prophylaxis
of infections in patients undergoing thoracotomy. Augmentation
by serrapeptase on tissue permeation of CTM was examined in
35 thoracotomy patients with lung cancer. The subjects were
divided into two groups according to the method of the administration
of CTM. Group I consisted of 17 subjects, each of whom received
a single dose of 2 g of CTM alone by an instillation for 30
minutes. Group II consisted of 18 subjects, each of whom received
a combination of CTM and serrapeptase; serrapeptase was given
2 tablets (10 mg) each time for three times/day until the day
before surgery, and then CTM was administered by the same procedure.
The following results were obtained: Individual difference
was observed for the permeation of CTM into tissues. Pathologic
differences also affected the permeation. Nevertheless, the
CTM levels in pulmonary tissues reached about a half of those
in the blood in both the single dose group and the combination
group, hence sufficient concentrations exceeding MIC80 for
main microorganisms that caused infections in the lung were
obtained. The concentrations of CTM in inflammatory tissues
have showed lower levels than those of normal tissues in both
CTM single dose and the combination groups. Decrease of blood
flow volume may have contributed to the reduction in levels
of CTM in the inflammatory tissues. The ratio of the concentration
of the drug in pulmonary tissues to that in the blood was 29.1
+/- 2.5% in the single dose group, and 44.2 +/- 6.0% in the
combination group, the latter showing quite a significant increase
(P less than 0.05). Combined administrations of CTM and serrapeptase
deserves more trials in the case when surgical treatments of
the lung are performed. An antiinflammatory effect of serrapeptase
in the respiratory system is expected, and in addition, the
combined use of CTM and serrapeptase should stimulate permeation
of the antibiotic into tissues. |
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