|
WAM Essentials, Inc.
Systemic Enzyme Therapy
... Allowing You to Live Your Passion!™ |
|
|
|
|
|
|
|
Oral therapy with proteolytic enzymes
decreases excessive TGF-b levels
in human blood
Desser L., Holomanova D.1,
Zavadova E. 2, Pavelka
K. 3, Mohr T., Herbacek
I.
Institute of Cancer Research, University of Vienna,
1Institute of Hematology and Transfusion Medicine,
University of Bratislava, Bratislava, Slovak Republic
2Dept. of Immunology, St. Elisabeth Hospital,
Prague, Czech Republic
3Institute of Rheumatology, Prague, Czech Republic
Cancer Chemother Pharmacol 2001, Vol. 47., Suppl: July.
S10 - S15
520 KA (2-13-3)-(20-00-2) |
|
Abstract
Therapy with oral proteolytic enzymes (OET) with combination
drug products containing papain, bromelain, trypsin, and
chymotrypsin has been shown to be beneficial in clinical
settings such as radiotherapy-induced fibrosis, bleomycin
pneumotoxicity and immunosuppression in cancer, all of which
are nowadays known to be accompanied by excessive transforming
growth factor-b (TGF- b) production. It
has been demonstrated that proteolytic enzymes reduce TGF- b levels
in serum by converting the protease inhibitor a2 macroglobulin
(a2M) from the "slow" form into the "fast" form,
whereby the "fast" form binds and inactivates TGF- b irreversibly.
In this study we have investigated the effect of OET on the
concentration of TGF- b 1 in serum of patients with
rheumatoid arthritis (RA) (n = 87), osteomyelofibrosis
(OMF) (n = 7) and herpes zoster (HZ) (n = 31).
Seventy-eight healthy volunteers served as controls. TGF- b 1
levels in serum were assessed by enzyme-linked immunosorbent
assay (ELISA). We have demonstrated that in healthy volunteers
and in patients there exists a correlation between active
and latent TGF- b 1 in serum (r = 0.8021;
-P<0.0001). Treatment with OET had no significant
effect on TGF- b 1 concentration in healthy volunteers
or patients with a normal level of TGF- b 1. In
patients with elevated TGF- b 1 concentration (>50ng/ml
serum), OET reduced TGF- b 1 in RA (P< 0.005),
in OMF (P< 0.05), and in HZ (P<0.05).
Conclusion: These results support the concept that
OET is beneficial in diseases characterized in part by TGF- b 1
overproduction. |
|
|
Medical Disclaimer: We believe
that the role of nutrition is important to good health, however,
this web site is for informational purposes only and is not
intended to be a substitute for professional medical advice.
Our goal is to provide you, the customer, with the information
necessary for you to make important nutritional and self-help
decisions. We strongly suggest that you share any products
you decide to use with your health care professional for optimal
individual health benefits. Women who are planning on becoming
pregnant or who are pregnant should not take any supplements
without consulting their physician first. Information and statements
on this website regarding dietary supplements have not been
evaluated by the Food and Drug Administration, and are not
intended to diagnose, treat, cure, mitigate or prevent any
disease or health condition.
|
|
|
© Copyright 2004 WAM Essentials,
Inc. All Rights Reserved.
None of the material contained herein may be reproduced without
the prior written consent of WAM Essentials, Inc. |
|
|